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  • Title: Four new diterpenoids isolated from the Euphorbia rapulum.
    Author: Liu XX, Shang L, Huang C, Feng XS, Li W, Sha Y, Huang J, Wang JH.
    Journal: J Asian Nat Prod Res; 2016 Sep; 18(9):823-30. PubMed ID: 27089930.
    Abstract:
    Four new diterpenoids named 1-epi-9-hydroxydepressin (1), 1-epi-8-hydroxydepressin (2), 2,13,9-trihydroxy-labda-8(17),12(E),14-triene (3) and tagalsin I (4) were isolated from Euphorbia rapulum. The structures of these compounds were elucidated by means of various spectroscopic methods. All the isolated compounds were evaluated for cytotoxic activities against HepG2, MCF-7, and C6 cell lines, and compound 4 showed moderate selective activity against MCF-7 cell line with an IC50 value of 31.8 μM.
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