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  • Title: Stability of vinca alkaloid anticancer drugs in three commonly used infusion fluids.
    Author: Beijnen JH, Vendrig DE, Underberg WJ.
    Journal: J Parenter Sci Technol; 1989; 43(2):84-7. PubMed ID: 2709240.
    Abstract:
    The chemical stabilities of the vinca alkaloid anticancer drugs vinblastine, vincristine, and vindesine have been studied in three commonly used infusion fluids at 4 and 25 degrees C. The infusion fluids were: 0.9% sodium chloride, 5% dextrose, and Ringer's Lactate injection. Stability has been measured by using a stability-indicating high performance liquid chromatographic assay with ultraviolet detection. At 4 degrees C no significant degradation of the vinca alkaloids occurred within a storage period of three weeks. The stability tests at 25 degrees C also revealed that vinblastine, vincristine, and vindesine are stable (greater than 95% remained) when stored for three weeks at this temperature in 5% dextrose, 0.9% sodium chloride, or Ringer's Lactate infusion fluids.
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