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  • Title: High-field dissolution dynamic nuclear polarization of [1-(13)C]pyruvic acid.
    Author: Yoshihara HA, Can E, Karlsson M, Lerche MH, Schwitter J, Comment A.
    Journal: Phys Chem Chem Phys; 2016 May 14; 18(18):12409-13. PubMed ID: 27093499.
    Abstract:
    [1-(13)C]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-(13)C]pyruvic acid, unextrapolated solution-state (13)C polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.
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