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  • Title: Effects of amino acid mutations in the pore-forming domain of the hemolytic lectin CEL-III.
    Author: Nagao T, Masaki R, Unno H, Goda S, Hatakeyama T.
    Journal: Biosci Biotechnol Biochem; 2016 Oct; 80(10):1966-9. PubMed ID: 27101707.
    Abstract:
    The hemolytic lectin CEL-III forms transmembrane pores in the membranes of target cells. A study on the effect of site-directed mutation at Lys405 in domain 3 of CEL-III indicated that replacements of this residue by relatively smaller residues lead to a marked increase in hemolytic activity, suggesting that moderately destabilizing domain 3 facilitates formation of transmembrane pores through conformational changes.
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