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  • Title: Modulation of catecholamine metabolism in synaptosomes by a neuroregulatory factor from mammalian brain.
    Author: Pastuszko A, Yee DK, Wilson DF.
    Journal: Neurosci Lett; 1989 Mar 13; 98(1):111-7. PubMed ID: 2710394.
    Abstract:
    Incubation of synaptosomes from rat brain with bovine brain extract caused inhibition of oxidative deamination of dopamine, decreased formation of 3,4-dihydroxyphenylacetic acid, increased formation of norepinephrine and its N-methyl derivatives and increased release of catecholamines. Omission of Ca2+ from the extrasynaptosomal medium completely blocked the brain extract induced release of [3H]catecholamines and decreased, by about 80%, the effect on changes in catecholamine metabolism. Chromatography of the brain extract on Sephadex-G25 columns resulted in an active compound eluting at the position expected for compounds with molecular weights in the region of 1500 to 2500 Da.
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