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  • Title: [Congestive cardiomyopathy after doxorubicin (adriamycin)author's transl)].
    Author: Kaduk B, Seiler G.
    Journal: Dtsch Med Wochenschr; 1977 Dec 09; 102(49):1813-7. PubMed ID: 271071.
    Abstract:
    Doxorubicin at a dose of 470 mg/m2 body surface, was administered to a 15-year-old boy with metastasising osteosarcoma. The cumulative dose caused severe "secondary congestive cardiomyopathy", which ended fatally, although the cumulative dose was below the recommended limit of 550 mg/m2. No other treatment for the tumour had been given. Postmortem examination revealed obliterative lesions in the intramural coronary vessels and electron-microscopy showed all the features of a cardiomyopathy at cellular level.
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