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  • Title: Chronic Progressive External Ophthalmoplegia in the Absence of Ptosis.
    Author: Bucelli RC, Lee MS, McClelland CM.
    Journal: J Neuroophthalmol; 2016 Sep; 36(3):270-4. PubMed ID: 27111092.
    Abstract:
    Classically defined as bilateral, symmetric, and progressive ophthalmoparesis with myopathic ptosis, chronic progressive external ophthalmoplegia (CPEO) rarely has been reported in the absence of ptosis. We describe 2 patients with CPEO and without ptosis who presented with binocular diplopia related to small-angle esodeviations, poor fusional amplitudes, and slow saccades. In both cases, hematological studies and neuroimaging ruled out alternative etiologies, whereas muscle biopsy showed findings of mitochondrial myopathy.
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