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  • Title: Relationship between hepatic glutathione content and carbon tetrachloride-induced hepatotoxicity in vivo.
    Author: Shimuzu M, Morita S, Yamano T, Yamada A.
    Journal: Toxicol Lett; 1989 Apr; 47(1):95-102. PubMed ID: 2711415.
    Abstract:
    The relationship between carbon tetrachloride (CCl4)-induced hepatotoxicity and hepatic glutathione (GSH) content was investigated in fed and fasted rats. The elevation of serum glutamic-pyruvic transaminase (GTP) activity by CCl4 treatment was enhanced by fasting. Although the hepatic GSH content fo 12-hour-fasted rats was higher than that of fed rats determined at 6 p.m., the serum GPT activity of the former was higher than that of the latter. Starvation had no effect on the activities of hepatic glutathione peroxidase (GSH-Px) and glutathione reductase (GR). The results suggest that the potentiation of hepatic injury by CCl4 cannot be related to hepatic GSH content.
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