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  • Title: [The mechanism coupling adrenergic and cholinergic influences on the smooth musculature of the small intestine].
    Author: Ovsiannikov VI, Tkachenko BI.
    Journal: Vestn Akad Med Nauk SSSR; 1989; (1):45-53. PubMed ID: 2711742.
    Abstract:
    Experimental results, substantiating the idea of a specific mechanism for the activation of small-intestinal smooth muscle by the adrenergic system are summarized. This mechanism is realized via catecholamines affecting excitatory beta-adrenoreceptors located on cholinergic interneurones of the myenteric plexus. The excitatory beta-adrenoreceptors are shown to contribute to the realization of small-intestinal motor responses to acetylcholine, vagal stimulation and 5-hydroxytryptamine, histamine, bradykinin. The data obtained are an evidence of physiological significance of this specific adrenosensitive input of small-intestinal cholinergic neurones. The cholinergic neurones are shown to participate in producing small-intestinal responses to 5-hydroxytryptamine, histamine, bradykinin, the responses being, for this reason, dependent on the level of catecholamines, stimulating excitatory beta-adrenoreceptors. It is suggested that cholinergic neurones of the enteric nervous system are under double adrenergic control: a stimulating effect of catecholamines mediated by excitatory beta-adrenoreceptors is counteracted by an inhibitory effect of alpha-adrenoreceptor activation by sympathetic neuromediator noradrenaline.
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