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  • Title: New steroidal saponins from the rhizomes of Paris delavayi and their cytotoxicity.
    Author: Liu Y, Tian X, Hua D, Cheng G, Wang K, Zhang L, Tang H, Wang M.
    Journal: Fitoterapia; 2016 Jun; 111():130-7. PubMed ID: 27118322.
    Abstract:
    Four new furostanol saponins, named padelaosides C-F (1-4), together with four known spirostanol saponins 5-8 were isolated from the rhizomes of Paris delavayi Franchet. Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical evidences. The discovery of the new compounds 1-4 extended the diversity and complexity of this furostanol saponin family. The cytotoxicity of all the saponins was evaluated for their cytotoxicity against human glioblastoma U87MG and human hepatocellular carcinoma Hep-G2 cell lines. The known spirostanol saponins 7 and 8 exhibited notable cytotoxicity against the two tumor cell lines with IC50 values of 1.13 and 3.42μM, respectively, while the new furostanol saponins 3 and 4 showed moderate cytotoxicity with IC50 values of 15.28 to 16.98μM.
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