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  • Title: Leg ulcers following subcutaneous injection of a liquid silicone preparation.
    Author: Rae V, Pardo RJ, Blackwelder PL, Falanga V.
    Journal: Arch Dermatol; 1989 May; 125(5):670-3. PubMed ID: 2712585.
    Abstract:
    We present an unusual case of leg ulcers occurring 23 years after the patient had received large-volume subcutaneous injections of a liquid silicone preparation into her legs for cosmetic reasons. Light microscopy of a biopsy specimen from the edge of the ulcer showed optically clear vacuoles in the dermis, together with a mixed cellular infiltrate. Scanning electron microscopic studies revealed amorphous spherules within the vacuoles, and energy-dispersive spectroscopy established the presence of silicon in these spherules. Nearby tissue not containing spherules did not show a silicon peak. This case adds to the growing documentation of morbidity associated with injections of silicone of uncertain purity.
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