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  • Title: [Morphobiophysical features of the duodenal mucosa in patients with duodenal ulcers].
    Author: Mogil'naia GM, Fisher AA, Gorban' VV.
    Journal: Arkh Patol; 1989; 51(2):35-40. PubMed ID: 2712727.
    Abstract:
    Chronic duodenitis in patients with duodenal ulcer is characterized by substantial morphofunctional changes in the mucosa, decreased transmural potential difference and definite patterns of carbohydrate-containing biopolymer production, the initial changes being manifested as neutral glycoprotein hypersecretion with their subsequent diminished synthesis rates, followed by a more pronounced drop of sialo- and sulfoglycoprotein levels. A correlation was found between the severity of duodenitis, morphometric and histochemical parameters, and gastric pepsin secretion rates (hypersecretion). It is suggested that these changes are etiopathogenetically common.
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