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  • Title: The influence of experimental conditions on the spectrin-hemoglobin interaction.
    Author: Vincentelli J, Fraboni A, Paul C, Schnek AG.
    Journal: Biol Chem Hoppe Seyler; 1989 Jan; 370(1):63-6. PubMed ID: 2713099.
    Abstract:
    Human spectrin, when isolated, purified and stored in such conditions that preserve its tetrameric form, is able to associate with human hemoglobin as it is clearly shown by gel filtration. However, this hemoglobin-spectrin association does not seem to have a significant effect on hemoglobin oxygenation as indicated by equilibrium and rapid kinetics measurements.
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