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  • Title: Seasonal variation in responsiveness of human eccrine sweat glands to phenylephrine.
    Author: Banjar WM, Bradshaw CM, Szabadi E.
    Journal: Br J Clin Pharmacol; 1989 Feb; 27(2):276-8. PubMed ID: 2713223.
    Abstract:
    The responses of eccrine sweat glands to intradermally injected phenylephrine were studied in six healthy male volunteers in two experiments carried out in February and June. Phenylephrine (10(-7)-10(-2) M, 50 microliters) had no consistent effect on sweat gland activity during February, but evoked dose-related increases in sweat gland activity during June. Responsiveness to phenylephrine could be antagonized by prazosin (10(-5) and 10(-4) M) added to the injection solution.
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