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  • Title: Insights into the structure-activity relationship of the anticancer compound ZJ-101: A critical role played by the cyclohexene ring.
    Author: Shah AK, Qian S, Zhang D, Head SA, Liu JO, Jin Z.
    Journal: Bioorg Med Chem Lett; 2016 Jun 15; 26(12):2890-2892. PubMed ID: 27133592.
    Abstract:
    Compound ZJ-101, a structurally simplified analog of the marine natural product superstolide A, was previously developed in our laboratory. In the subsequent structure-activity relationship study, a new analog ZJ-102 was designed and synthesized to probe the importance of the cyclohexenyl group through its replacement to a phenyl group using a concise and convergent synthetic approach. The biological evaluation showed that this new analog ZJ-102 is significantly less active against cancer cells in vitro than ZJ-101, suggesting that the cyclohexenyl ring (along with its two stereogenic centers) present in ZJ-101 is important for its anticancer activity.
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