These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Regulation of the biosynthetic pathway of aromatic amino acids in Nocardia mediterranei.
    Author: Xia TH, Chiao JS.
    Journal: Biochim Biophys Acta; 1989 Apr 25; 991(1):6-11. PubMed ID: 2713423.
    Abstract:
    The regulation of enzymes in the biosynthetic pathway of aromatic amino acids in Norcardia mediterranei was studied. Anthranilate synthase was sensitive to feedback inhibition by very low concentrations of LTrp, and kinetic analysis showed that LTrp was competitive with respect to chorismate; the five enzymes in LTrp biosynthesis pathway, anthranilate synthase (AS), anthranilate-phosphoribosylpyrophosphate phosphoribosyltransferase (PRT), N-5'-phosphoribosylanthranilate isomerase (PRAI), indole-3-glycerol phosphate synthetase (InGPS) and tryptophan synthase (TS), were all repressed by LTrp; LTyr and LPhe inhibited chorismate mutase. Prephenate dehydratase activity was greatly inhibited by LPhe and activated by LTyr, nearly 60% of its activity was inhibited by 5 microM of LPhe, and 20 microM of LTyr increased the activity approx. 3-fold. In addition, the effects of LPhe and LTyr on prephenate dehydratase were highly specific. The regulatory circuit of the biosynthetic pathway of aromatic amino acids in N. mediterranei is presented.
    [Abstract] [Full Text] [Related] [New Search]