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  • Title: Experimental studies on the olfactory marker protein. V. Olfactory marker protein in the olfactory neurons transplanted within the olfactory bulb.
    Author: Monti Graziadei AG, Graziadei PP.
    Journal: Brain Res; 1989 Apr 10; 484(1-2):157-67. PubMed ID: 2713678.
    Abstract:
    The olfactory mucosa of neonatal rats was transplanted within the olfactory bulb of littermates to investigate whether the olfactory bulb would have played a role in the differentiation of the olfactory neurons and whether the olfactory axons, growing out from the transplant, would have interacted with the olfactory glomeruli of the host. The observations were conducted on sections stained with Gill's hematoxylin, Loots' silver method, and the immunohistochemical technique for the demonstration of the olfactory marker protein (OMP). The olfactory neurons of the transplant (those localized in the neuroepithelium and those migrating from it into the bulbar parenchyma) could become fully differentiated but only few of them were OMP positive. Numerous sensory axons originated from the transplanted olfactory mucosa, however, they did not form ectopic glomeruli nor did they interact with the glomeruli of the host. These results indicate that the olfactory bulb, in vivo, does not affect the number of olfactory neurons expressing OMP and that the ectopically located neurons lack the cues to recognize the host glomeruli.
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