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  • Title: Allergen immunotherapy for birch pollen-allergic patients: recent advances.
    Author: Moingeon P, Floch VB, Airouche S, Baron-Bodo V, Nony E, Mascarell L.
    Journal: Immunotherapy; 2016 May; 8(5):555-67. PubMed ID: 27140409.
    Abstract:
    As of today, allergen immunotherapy is performed with aqueous natural allergen extracts. Recombinant allergen vaccines are not yet commercially available, although they could provide patients with well-defined and highly consistent drug substances. As Bet v 1 is the major allergen involved in birch pollen allergy, with more than 95% of patients sensitized to this allergen, pharmaceutical-grade recombinant Bet v 1-based vaccines were produced and clinically tested. Herein, we compare the clinical results and modes of action of treatments based on either a birch pollen extract or recombinant Bet v 1 expressed as hypoallergenic or natural-like molecules. We also discuss the future of allergen immunotherapy with improved drugs intended for birch pollen-allergic patients suffering from rhinoconjunctivitis.
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