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  • Title: [Brown urine : Myoglobin-induced renal failure after concomitant administration of simvastatin and amiodarone].
    Author: Pietsch U, Müller-Höcker C, Filipovic M.
    Journal: Anaesthesist; 2016 May; 65(5):366-8. PubMed ID: 27142363.
    Abstract:
    Rhabdomyolysis is a rare but well-known complication of statin therapy. The risk is considerably increased when concomitant drugs are administered that inhibit metabolism and breakdown via the cytochrome CYP3A4. We report a case of myoglobin-induced acute renal failure secondary to the concomitant use of simvastatin and amiodarone. The risk of rhabdomyolysis is mainly determined by the statin dose; in the case of the concomitant use of CYP3A4 inhibitors, a maximal daily dose of 20 mg is recommended to avoid harmful drug interactions.
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