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  • Title: Hyaluronate in healing of corneal alkali wound in the rabbit.
    Author: Chung JH, Fagerholm P, Lindström B.
    Journal: Exp Eye Res; 1989 Apr; 48(4):569-76. PubMed ID: 2714415.
    Abstract:
    The effect of topically applied 1% and 2% sodium hyaluronate was studied on the healing of a standardized rabbit corneal alkali wound. The healing of the epithelium, the stroma, and the endothelium was evaluated separately by applying quantitative methods. The healing was followed for 8 weeks. Both 1% and 2% sodium hyaluronate have a statistically significant positive influence on the epithelial re-surfacing, especially during the late healing phase. Furthermore, sodium hyaluronate has a positive healing influence on the stromal healing at a certain time interval during the observation period. This was reflected as a better maintained stromal dry mass level compared to control. The stromal healing was parallel to a faster re-surfacing of the endothelium.
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