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  • Title: Prenatally Diagnosed Aggressive Intracranial Immature Teratoma-Clinicopathological Correlation.
    Author: Nariai H, Price DE, Jada A, Weintraub L, Weidenheim KM, Gomes WA, Levy AS, Abbott R, Malbari F.
    Journal: Fetal Pediatr Pathol; 2016; 35(4):260-4. PubMed ID: 27158748.
    Abstract:
    OBJECTIVE: To describe clinicopathological correlation of congenital intracranial immature teratoma. METHODS: A retrospective case analysis from a tertiary medical center. RESULTS: We report a case of an intracranial immature teratoma detected prenatally at 35 weeks of gestation. The tumor showed rapid growth, causing acute hydrocephalus requiring subsequent ventriculoperitoneal shunting. Resective surgery was performed within 2 weeks after birth. The infant died at day of life 29. Histological examination revealed an immature teratoma, with high MIB1/Ki-67 proliferation index. CONCLUSION/IMPLICATIONS: Intracranial immature teratoma with high MIB1/Ki-67 proliferation index may serve as an independent poor prognostic factor.
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