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  • Title: Method-dependent Discrepancies in Fetal Hemoglobin Quantification in Patients With Hemoglobin S.
    Author: Creary SE, Pyle-Eilola AL, Varga E, Cotten SW, S Lorey T, Holmes DT, Greene DN.
    Journal: J Pediatr Hematol Oncol; 2016 Jul; 38(5):402-5. PubMed ID: 27164532.
    Abstract:
    Hemoglobin F (HbF) concentration is used in the diagnosis of certain hemoglobinopathies and accurate quantification is central to treatment of patients with sickle cell disease. The 2 most commonly used methods to quantify HbF are high performance liquid chromatography and capillary zone electrophoresis. This study reports discrepancies in HbF quantification between these methods when hemoglobin S is present in the sample. Clinicians and investigators should be mindful of the method used for HbF quantification when evaluating and treating patients who produce hemoglobin S.
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