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Title: Endothelial Barrier and Metabolism: New Kids on the Block Regulating Bone Marrow Vascular Niches. Author: Harjes U, Verfaillie C, Carmeliet P. Journal: Dev Cell; 2016 May 09; 37(3):210-2. PubMed ID: 27165553. Abstract: The vasculature of the bone marrow remains poorly characterized, yet crucial to maintain hematopoiesis and retain stem cells in a quiescent state. A recent study by Itkin et al. (2016) in Nature reports how vascular barrier integrity and endothelial cell metabolism regulate hematopoietic stem cell quiescence and leukocyte trafficking.[Abstract] [Full Text] [Related] [New Search]