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  • Title: Antibodies to hepatitis B virus surface antigen and survival of hemodialysis patients - a prospective study.
    Author: Grzegorzewska AE, Świderska MK, Warchoł W.
    Journal: Expert Rev Vaccines; 2016 Aug; 15(8):1063-74. PubMed ID: 27166852.
    Abstract:
    BACKGROUND: Antibodies to hepatitis B virus (HBV) surface antigen (anti-HBs) may develop in response to HBV vaccination or infection. We investigated whether anti-HBs are an independent predictor of survival in hemodialysis (HD) patients. METHODS: A 6-year prospective study was conducted in 532 HD patients. Survival analyses were performed using the Kaplan-Meier method and the Cox proportional hazard model. RESULTS: In HBV non-infected patients, age (P = 0.005), coronary artery disease (P = 0.002), and non-response to HBV vaccine (P = 0.008) were the independent risk factors of all-cause mortality. In HBV infected patients, the only independent predictor of all-cause mortality was coronary artery disease (P = 0.002). CONCLUSION: The ability to produce the protective anti-HBs titer in response to HBV vaccine is a positive predictor of survival in HBV non-infected HD patients.
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