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  • Title: Influence of Chest Compressions on Circulation during the Peri-Cardiac Arrest Period in Porcine Models.
    Author: Xu J, Li C, Li Y, Walline J, Zheng L, Fu Y, Yao D, Zhu H, Liu X, Chai Y, Wang Z, Yu X.
    Journal: PLoS One; 2016; 11(5):e0155212. PubMed ID: 27168071.
    Abstract:
    OBJECTIVE: Starting chest compressions immediately after a defibrillation shock might be harmful, if the victim already had a return of spontaneous circulation (ROSC) and yet was still being subjected to external compressions at the same time. The objective of this study was to study the influence of chest compressions on circulation during the peri-cardiac arrest period. DESIGN: Prospective, randomized controlled study. SETTING: Animal experimental center in Peking Union Medical Collage Hospital, Beijing, China. SUBJECTS: Healthy 3-month-old male domestic pigs. INTERVENTIONS: 44 pigs (28±2 kg) were randomly assigned to three groups: Group I (non-arrested with compressions) (n = 12); Group II (arrested with compressions only) (n = 12); Group III (ROSC after compressions and defibrillation) (n = 20). In Groups I and II, compressions were performed to a depth of 5cm (Ia and IIa, n = 6) or a depth of 3cm (Ib and IIb, n = 6) respectively, while in Group III, the animals which had just achieved ROSC (n = 18) were compressed to a depth of 5cm (IIIa, n = 6), a depth of 3cm (IIIb, n = 6), or had no compressions (IIIc, n = 6). Hemodynamic parameters were collected and analyzed. MEASUREMENTS AND FINDINGS: Hemodynamics were statistically different between Groups Ia and Ib when different depths of compressions were performed (p < 0.05). In Group II, compressions were beneficial and hemodynamics correlated with the depth of compressions (p < 0.05). In Group III, compressions that continued after ROSC produced a reduction in arterial pressure (p < 0.05). CONCLUSIONS: Chest compressions might be detrimental to hemodynamics in the early post-ROSC stage. The deeper the compressions were, the better the effect on hemodynamics during cardiac arrest, but the worse the effect on hemodynamics after ROSC.
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