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  • Title: Total Synthesis of (+)-Minfiensine: Construction of the Tetracyclic Core Structure by an Asymmetric Cascade Cyclization.
    Author: Zhang ZX, Chen SC, Jiao L.
    Journal: Angew Chem Int Ed Engl; 2016 Jul 04; 55(28):8090-4. PubMed ID: 27172972.
    Abstract:
    A new method for one-step construction of the tetracyclic core structure of the indole alkaloid (+)-minfiensine was developed utilizing a palladium-catalyzed asymmetric indole dearomatization/iminium cyclization cascade. An efficient total synthesis of (+)-minfiensine was realized using this strategy. The present method enables access to the common core structure of a series of monoterpene indole alkaloids, such as vincorine, echitamine, and aspidosphylline A.
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