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  • Title: Two new sesquiterpenoid glycosides from the leaves of Lycium barbarum.
    Author: Wang Y, Zhao B, Ma HR, Aisa HA.
    Journal: J Asian Nat Prod Res; 2016 Sep; 18(9):871-7. PubMed ID: 27176709.
    Abstract:
    Two new sesquiterpenoid glycosides, lyciumionosides A-B (1-2), together with four known compounds (3-6), were isolated from the leaves of Lycium barbarum. Their structures were mainly established on the basis of MS, 1D and 2D NMR spectroscopic techniques. The antiproliferative activities of compounds 1-5 were evaluated. Compound 1 showed highest inhibitory activity against A549 cells with IC50 value of 32.6 ± 2.6 μM, compound 3 showed highest inhibitory activity against PC-3 cells with IC50 value of 36.0 ± 2.9 μM, and compound 5 exhibited highest inhibitory activity against HeLa cells with IC50 value of 32.3 ± 4.2 μM.
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