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  • Title: Hepatitis B plasmonic biosensor for the analysis of clinical serum samples.
    Author: Riedel T, Surman F, Hageneder S, Pop-Georgievski O, Noehammer C, Hofner M, Brynda E, Rodriguez-Emmenegger C, Dostálek J.
    Journal: Biosens Bioelectron; 2016 Nov 15; 85():272-279. PubMed ID: 27179568.
    Abstract:
    A plasmonic biosensor for rapid detection of protein biomarkers in complex media is reported. Clinical serum samples were analyzed by using a novel biointerface architecture based on poly[(N-(2-hydroxypropyl) methacrylamide)-co-(carboxybetaine methacrylamide)] brushes functionalized with bioreceptors. This biointerface provided an excellent resistance to fouling even after the functionalization and allowed for the first time the direct detection of antibodies against hepatitis B surface antigen (anti-HBs) in clinical serum samples using surface plasmon resonance (SPR). The fabricated SPR biosensor allowed discrimination of anti-HBs positive and negative clinical samples in 10min. Results are validated by enzyme-linked immunoassays of the sera in a certified laboratory. The sensor could be regenerated by simple treatment with glycine buffer.
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