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  • Title: [Arterial hypertension and fatty acids of the blood in patients with chronic glomerulonephritis without the nephrotic syndrome].
    Author: Neverov NI, Kozlova RI, Mukhin NA.
    Journal: Urol Nefrol (Mosk); 1989; (1):59-63. PubMed ID: 2718286.
    Abstract:
    The study involved 33 patients with chronic glomerulonephritis of hypertonic type (CGNHT), in their number 8 with the signs of a moderate renal failure, 25 with a latent form of the disease (CGNLF), 10 ones with hypertension, and 20 healthy age-matched subjects. Patients with CGNHT and hypertension patients were comparatively studies for the blood pressure values. Fatty acid, glycerine, malonic dialdehyde contents were investigated in all the examinees. Some patients were studied for the fraction composition of fatty acids as well. The majority of CGNHT and hypertensive patients demonstrated a significant increase in the levels of fatty acids, glycerine and malonic dialdehyde versus healthy and CGNLF subjects, whereas the content of polyunsaturated fatty acids was found to be decreased (exemplified by linoleic acid) and the content of monounsaturated ones increased (exemplified by myristic acid). The aforementioned changes were mostly pronounced in those CGNHT patients who had higher systolic pressure whereas the signs of renal failure were of no importance for the value variance. No differences were revealed in the parameters of hypertensive and CGNHT patients. Accounting for the role of fatty acids, polyunsaturated ones predominantly, which provide the energy consumption of myocardium (raised in those with higher blood pressure values) the authors suggested that arterial hypertension played a definite role in the aforementioned alterations. The results obtained could be of a certain clinical value for dietetic and medicamentous improvement of the deficiency in the levels of polyunsaturated fatty acids in the patients with CGNHT, possible normalization of fatty acid content and composition during the decrease of the blood pressure.
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