These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [A new highly active proteolytic myelin enzyme and its possible role in the mechanism of the demyelinating process].
    Author: Savchenko IuN, Zavalishin IA, Zakharova MN, Khrustaleva NA, Khokhlov AP.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1989; 89(1):49-53. PubMed ID: 2718665.
    Abstract:
    The study of the myelin in the rabbit brain and in biological fluids of patients with multiple sclerosis has revealed the presence of a new highly active proteolytic enzyme. The article describes the physicochemical properties of this enzyme. Its role in the pathogenesis of the demyelinizing process is emphasized: normally being coupled with an inhibitor the enzyme is released as a result of the demyelinizing process and becomes active. This leads to the destruction of myelin proteins. Possible factors of enzyme activation are considered. The authors discuss the significance of differences in the activities depending on the stage of the process and the course of multiple sclerosis.
    [Abstract] [Full Text] [Related] [New Search]