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  • Title: Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex.
    Author: Venkatesh V, Wedge CJ, Romero-Canelón I, Habtemariam A, Sadler PJ.
    Journal: Dalton Trans; 2016 Aug 16; 45(33):13034-7. PubMed ID: 27189101.
    Abstract:
    We report the synthesis and characterisation of the nitroxide spin-labelled photoactivatable Pt(iv) prodrug trans,trans,trans-[Pt(N3)2(OH)(OCOCH2CH2CONH-TEMPO)(Py)2] (Pt-TEMPO, where TEMPO = 2,2,6,6-tetramethylpiperidine 1-oxyl). Irradiation with blue visible light gave rise to Pt(ii) and azidyl as well as nitroxyl radicals. Pt-TEMPO exhibited low toxicity in the dark, but on photoactivation was as active towards human ovarian cancer cells as the clinical photosensitizer chlorpromazine and much more active than the anticancer drug cisplatin under the conditions used.
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