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  • Title: The Molecules of Sperm Exocytosis.
    Author: Belmonte SA, Mayorga LS, Tomes CN.
    Journal: Adv Anat Embryol Cell Biol; 2016; 220():71-92. PubMed ID: 27194350.
    Abstract:
    Exocytosis is a fundamental process used by eukaryotic cells to release biological compounds and to insert lipids and proteins in the plasma membrane. Specialized secretory cells undergo regulated exocytosis in response to physiological signals. Sperm exocytosis or acrosome reaction (AR) is essentially a regulated secretion with special characteristics. We will focus here on some of these unique features, covering the topology, kinetics, and molecular mechanisms that prepare, drive, and regulate membrane fusion during the AR. Last, we will compare acrosomal release with exocytosis in other model systems.
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