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  • Title: Failure of combination therapy for Staphylococcus aureus bone infection: a case of in vivo selection with resistance to rifampicin and fusidic acid.
    Author: Aubin GG, Bémer P, Guillouzouic A, Launay E, Geffroy L, Touchais S, Corvec S.
    Journal: Infect Dis (Lond); 2016 Sep; 48(9):699-702. PubMed ID: 27194514.
    Abstract:
    Staphylococcus aureus is one of the main etiologies of bone and device-related infections. Treatment of these orthopedic infections combines mostly rifampicin with other antibiotics. The recurrence or failure rate after fusidic acid/rifampicin treatment remains low (<10%). We discuss here a case of antibiotic treatment failure for Staphylococcus aureus bone infection with in vivo selection of rifampicin and fusidic acid resistance. We also report a new mutation in fusA gene involved in fusidic acid resistance.
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