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  • Title: Role of calcium in the phenylephrine-induced activation of phosphorylase "A" in isolated liver cells.
    Author: Saz JM, Gonzalez-Manchon C, Ayuso MS, Parrilla R.
    Journal: Biochem Biophys Res Commun; 1989 Apr 28; 160(2):480-5. PubMed ID: 2719676.
    Abstract:
    The ability of phenylephrine to activate phosphorylase in liver cells with variable degrees of Ca2+ loading was studied. Phenylephrine has been found to be capable of stimulating phosphorylase at saturating Ca2+ concentrations that precluded any further action of this ion. Furthermore the degree of activation was proportional to the cellular calcium content. These results allow to conclude that alpha-adrenergic agonists activate phosphorylase by a mechanism apparently unrelated to their ability to mobilize and subsequently increase the cytosolic concentration of free Ca2+.
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