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  • Title: Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents.
    Author: Zhang X, Khalidi O, Kim SY, Wang R, Schultz V, Cress BF, Gross RA, Koffas MAG, Linhardt RJ.
    Journal: Bioorg Med Chem Lett; 2016 Jul 01; 26(13):3089-3092. PubMed ID: 27210435.
    Abstract:
    A series of 5,7-dihydroxyflavanone derivatives were efficiently synthesized. Their antimicrobial efficacy on Gram-negative, Gram-positive bacteria and yeast were evaluated. Among these compounds, most of the halogenated derivatives exhibited the best antimicrobial activity against Gram-positive bacteria, the yeast Saccharomyces cerevisiae, and the Gram-negative bacterium Vibrio cholerae. The cytotoxicities of these compounds were low as evaluated on HepG2 cells using a cell viability assay. This study suggests that halogenated flavanones might represent promising pharmacological candidates for further drug development.
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