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  • Title: Cytotoxic Steroidal Glycosides from the Whole Plant of Calamus acanthophyllus.
    Author: Prawat H, Mahidol C, Kaweetripob W, Intachote P, Pisutjaroenpong S, Ruchirawat S.
    Journal: Planta Med; 2016 Jul; 82(11-12):1117-21. PubMed ID: 27220076.
    Abstract:
    A new steroidal glycoside, callaphylloside (1), together with seven known glycosides (2-8), was isolated from the whole plant of Calamus acanthophyllus. The structure of the new compound was elucidated by spectral data analyses and chemical transformations. Compounds 5 and 8 exhibited strong cytotoxic activity against four cancer cell lines (0.7 ≤ IC50 ≤ 3.4 µM). Evaluation of the structure-activity relationship among steroidal glycosides revealed that the structure of spirostanol with an α-L-rhamnopyranosyl linked to C-2 of the inner glucopyranosyl residue both play a critical role in the effects of these compounds on the cancer cell lines.
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