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  • Title: Osteopenia in inhabitants with renal dysfunction induced by exposure to environmental cadmium.
    Author: Kido T, Nogawa K, Yamada Y, Honda R, Tsuritani I, Ishizaki M, Yamaya H.
    Journal: Int Arch Occup Environ Health; 1989; 61(4):271-6. PubMed ID: 2722250.
    Abstract:
    Bone density was measured in 28 women with itai-itai disease, 92 men and 114 women with cadmium-induced renal dysfunctions and 44 men and 66 women living in the three different non-polluted areas using a microdensitometer. The values of both indices corresponding to cortical width and bone mineral content were significantly lower in itai-itai disease patients than the cadmium-exposed women with renal dysfunctions and the non-exposed subjects. The cadmium-exposed women also showed a decrease in bone density compared with the non-exposed subjects. A significant decrease in bone density was also observed between cadmium-exposed men and the non-exposed subjects, although the difference was not as clear as in the women. The present study indicates that exposure to cadmium could cause marked osteopenia, particularly in the women.
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