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  • Title: Vacuolated lymphocytes in type II glycogenosis--a diagnostic approach?
    Author: von Bassewitz DB, Bremer HJ, Bourgeois M, Gröbe H, Stoermer J.
    Journal: Eur J Pediatr; 1977 Dec 30; 127(1):1-7. PubMed ID: 272287.
    Abstract:
    Using electron microscopy, glycogen-filled lysosomes were found in peripheral lymphocytes in 5 cases of the infantile form of glycogenosis type II. In two infants whose blood smears were available, the ultrastructural demonstration of this pathognomonic storage corresponded to well-delineated vacuoles detected by routine light microscopy. Detection of such vacuoles in peripheral lymphocytes by light microscopy and demonstration of glycogen-filled lysosomes by electron microscopy could be a simple and harmless tool for diagnosing the classical form of type II glycogenosis.
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