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  • Title: Hyperbilirubinemia in Preterm Neonates.
    Author: Bhutani VK, Wong RJ, Stevenson DK.
    Journal: Clin Perinatol; 2016 Jun; 43(2):215-32. PubMed ID: 27235203.
    Abstract:
    Preterm neonates with increased bilirubin production loads are more likely to sustain adverse outcomes due to either neurotoxicity or overtreatment with phototherapy and/or exchange transfusion. Clinicians should rely on expert consensus opinions to guide timely and effective interventions until there is better evidence to refine bilirubin-induced neurologic dysfunction or benefits of bilirubin. In this article, we review the evolving evidence for bilirubin-induced brain injury in preterm infants and highlight the clinical approaches that minimize the risk of bilirubin neurotoxicity.
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