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  • Title: The effect of diphenylhydantoin on fibroblasts in vitro.
    Author: da Keith, Paz MA, Gallop PM.
    Journal: J Dent Res; 1977 Oct; 56(10):1279-83. PubMed ID: 272395.
    Abstract:
    It was found that 0.02 mM was the higher concentration of drug which is not toxic and is compatible with normal cell morphology and growth over a period of a week. Using this concentration of drug there was no consistent stimulation of cell growth. A small increase in cell number was noted, however, in some cultures during the first 24 hours of culture. DpH at a concentration of 0.02 mM in the presence of ascorbic acid decreased collagen prolyl hydroxylation in "old" W1-38 cultures but a concentration of 0.1 mM was required to decrease the values to a similar extent in "young" cultures. A concentration of 0.02 mM DpH had no effect on hydroxylation in an "old" HGF culture. It is speculated that in a responsive individual a reduction of collagen prolyl hydroxylation may play a role in the etiology of DpH-induced gingival enlargement and congenital malformations.
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