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  • Title: Diagnosis and Clinical Genetics of Cushing Syndrome in Pediatrics.
    Author: Stratakis CA.
    Journal: Endocrinol Metab Clin North Am; 2016 Jun; 45(2):311-28. PubMed ID: 27241967.
    Abstract:
    Endogenous Cushing syndrome (CS) in pediatrics is rare; it may be caused by tumors that produce corticotropin in the pituitary gland or elsewhere, tumors that produce corticotropin-releasing hormone anywhere, and adrenocortical masses that produce cortisol. Adrenocortical cancer is a rare cause of CS in children but should be excluded first. CS in children is often caused by germline or somatic mutations with implications for patient prognosis and for their families. CS should be recognized early in children; otherwise, it can lead to significant morbidity and mortality. Patients with suspected CS should be referred to specialized clinical centers for workup.
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