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  • Title: Synthesis and antimicrobial properties of substituted beta-aminoxypropionyl penicillins and cephalosporins.
    Author: Balsamo A, Broccali G, Lapucci A, Macchia B, Macchia F, Orlandini E, Rossello A.
    Journal: J Med Chem; 1989 Jun; 32(6):1398-401. PubMed ID: 2724308.
    Abstract:
    Some beta-aminoxypropionyl penicillins (3) and cephalosporins (4 and 5), planned on the basis of the hypothesis that the (methyleneaminoxy)methyl group (greater than C = NOCH2) could be a "bioisoster" of either aryls or other aromatic groups, were synthesized and assayed for their antimicrobial properties. Compounds 3-5, tested on Gram-positive and Gram-negative bacteria, both sensitive to enzyme inactivation and otherwise, exhibited an activity trend that was not substantially different from that of the corresponding phenylacetamido derivatives taken as terms of comparison.
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