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  • Title: Elastin-Based Rubber-Like Hydrogels.
    Author: Desai MS, Wang E, Joyner K, Chung TW, Jin HE, Lee SW.
    Journal: Biomacromolecules; 2016 Jul 11; 17(7):2409-16. PubMed ID: 27257908.
    Abstract:
    We developed rubber-like elastomeric materials using a natural elastin derived sequence and genetic engineering to create precisely defined elastin-like polypeptides. The coiled elastin-like polypeptide chains, which behave like entropic springs, were cross-linked using an end-to-end tethering scheme to synthesize simple hydrogels with excellent extensibility and reversibility. Our hydrogels extend to strains as high as 1500% and remain highly resilient with elastic recovery as high as 94% even at 600% strain, significantly exceeding any other protein-based hydrogel. These materials are valuable as elastomeric hydrogels for designing extremely robust scaffolds useful for tissue engineering.
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