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  • Title: Modulation of Cardiac Potassium Current by Neural Tone and Ischemia.
    Author: Tomson TT, Arora R.
    Journal: Card Electrophysiol Clin; 2016 Jun; 8(2):349-60. PubMed ID: 27261826.
    Abstract:
    The cardiac action potential is generated by intricate flows of ions across myocyte cell membranes in a coordinated fashion to control myocardial contraction and the heart rhythm. Modulation of the flow of these ions in response to a variety of stimuli results in changes to the action potential. Abnormal or altered ion currents can result in cardiac arrhythmias. Abnormalities of autonomic regulation of potassium current play a role in the genesis of cardiac arrhythmias, and alterations in acetylcholine-activated potassium channels may play a key role in atrial fibrillation. Ischemia is another important modulator of cardiac cellular electrophysiology.
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