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  • Title: [Effect of 1-alpha oxyvitamin D3 on bone tissue in systemic osteoporosis].
    Author: Rodionova SS, Zatsepin ST, Shvets VN.
    Journal: Ortop Travmatol Protez; 1989 Feb; (2):37-40. PubMed ID: 2726218.
    Abstract:
    Prolonged administration of oxydevit (I alpha OH D3), a synthetic analogue of the active metabolite of vitamin D (I alpha 25, (OH)2D3) in patients with systemic osteoporosis inhibited the progress of the process. Abatement of the pain syndrome and increase in physical activity were accompanied by stabilization of the roentgenologic picture and of such parameters of the bone tissue as volume density of the spongy bone and thickness of the trabeculae. The mechanism of action of the drug is not quite clear, but importance is attached to the influence of the drug on the absorption of calcium from the intestines and to persistent normalization of the level of calcium in the blood. Taking into consideration the course of such disease as systemic osteoporosis, the inhibitory impact should be regarded as achievement of therapeutic effect.
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