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  • Title: Channel open time and metabolic stability of synaptic and extrasynaptic acetylcholine receptors on cultured chick myotubes.
    Author: Schuetze SM, Frank EF, Fischbach GD.
    Journal: Proc Natl Acad Sci U S A; 1978 Jan; 75(1):520-3. PubMed ID: 272669.
    Abstract:
    The mean channel open time and metabolic stability of acetylcholine receptors were studied in developing chick muscle fibers in vitro. Analysis of acetylcholine noise recorded from small patches of surface membrane on uninnervated myotubes indicates that the mean ionic channel open time is independent of receptor density. On myotubes innervated in vitro by spinal cord neurons, the mean open time of synaptic receptors was identical to that of extrasynaptic receptors on the same fibers. Receptor stability was estimated by autoradiography of cultures labeled with 125I-labeled alpha-bungarotoxin. Synaptic and extrasynaptic toxin--receptor complexes disappear at the same, relatively rapid rate. Both the mean channel open time and the apparent rate of receptor degradation are comparable to values obtained at extrasynaptic sites on denervated adult muscles in other species.
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