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  • Title: The appetite suppressant, d-fenfluramine, decreases self-stimulation at a feeding site in the lateral hypothalamus.
    Author: McClelland RC, Sarfaty T, Hernandez L, Hoebel BG.
    Journal: Pharmacol Biochem Behav; 1989 Feb; 32(2):411-4. PubMed ID: 2726999.
    Abstract:
    In prior studies rats showed a relative shift from self-stimulation to escape (i.e., from reward to aversion) following a large meal, obesity or anorectic doses of insulin. Racemic fenfluramine, on the other hand, decreased both self-stimulation and escape suggesting it had a general behavior suppressant property. To avoid the depressive, antidopaminergic effects of the l-isomer, this study tested the d-isomer which is primarily serotonergic. Rats were screened for stimulation-induced feeding and then trained to self-stimulate with one lever in 5-min periods that alternated with 5-min periods of automatic stimulation from which the animal could escape with a different lever. d-Fenfluramine (1.5-4.5 mg/kg IP) caused a dose-related decrease in self-stimulation. Stimulation-escape was relatively unaffected. This is interpreted as a decrease in feeding reward due to d-fenfluramine.
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