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  • Title: Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats.
    Author: Chauhan SS, Singh SK, Misra UK.
    Journal: Toxicology; 1989 May 31; 56(1):95-105. PubMed ID: 2728010.
    Abstract:
    The effect of fly ash inhalation on xenobiotic metabolizing enzymes and heme metabolism in lung and liver has been studied in rats. Fly ash inhalation induced pulmonary and hepatic cytochrome P-450 content, aryl hydrocarbon hydroxylase and glutathione S-transferase activity. Induction of cytochrome P-450 was accompanied by induction of delta-amino levulinic acid synthetase in lung and inhibition of heme oxygenase in both lung and liver. Fly ash inhalation induced those species of cytochrome P-450 which closely resembled cytochrome P-448 in spectral properties and electrophoretic mobility.
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