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  • Title: [Change in the influenza virus upon multiplication in the presence of high concentrations of remantadine].
    Author: Karako NI, Boreko EI, Kirillov VA, Votiakov VI.
    Journal: Vopr Virusol; 1989; 34(1):43-6. PubMed ID: 2728406.
    Abstract:
    It was established that classical fowl plague virus Rostock (H7N1) propagated in culture to which 10-25 micrograms/ml of remantadine had been added differed from the original FPV and its remantadine-resistant variant by markedly reduced infectious and hemagglutinating activity and, to a lesser extent, neuraminidase activity, lower amounts of M protein and hemagglutinin, incomplete cleavage of hemagglutinin, and significant loss of spikes on the virion surface.
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