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  • Title: Antibacterial activities of fluorescent nano assembled triphenylamine phosphonium ionic liquids.
    Author: Brunel F, Lautard C, Garzino F, Giorgio S, Raimundo JM, Bolla JM, Camplo M.
    Journal: Bioorg Med Chem Lett; 2016 Aug 01; 26(15):3770-3. PubMed ID: 27287371.
    Abstract:
    Staphylococcus aureus, a Gram positive coccal bacterium is a major cause of nosocomial infection. We report the synthesis of new triphenylamine phosphonium ionic liquids which are able to self-assemble into multiwall nanoassemblies and to reveal a strong bactericidal activity (MIC=0.5mg/L) for Gram positive bacteria (including resistant strains) comparable to that of standard antibiotics. Time kill, metabolism and fluorescence confocal microscopy studies show a quasi-instantaneously penetration of the nanoassemblies inside the bacteria resulting of a rapid blocking (30min) of their proliferation. As confirmed by rezasurin reduction monitoring, these compounds strongly affect the bacterial metabolism and a Gram positive versus Gram negative selectivity is clearly observed. These fluorescent phosphonium ionic liquid might constitute a useful tool for both translocation studies and to tackle infectious diseases related to the field of implantology.
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